該系統命名為“神探夏洛克（SHERLOCK，Specific High Sensitivity Enzymatic Reporter UnLOCKing）”?？梢杂糜跈z測血清、尿液和唾液中低濃度的寨卡病毒，而且可以用于檢測病毒載量，區分不同的菌株，甚至能分辨獨有不同耐藥突變的肺炎菌株和不同的癌癥突變。
又是一篇科學（Science）文章，祝賀華裔大神在“神”的道路上繼續高速前進。
原文摘要：
Nucleic acid detection with CRISPR-Cas13a/C2c2
Abstract：Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting CRISPR effector Cas13a (previously known as C2c2) exhibits a "collateral effect" of promiscuous RNAse activity upon target recognition. We combine the collateral effect of Cas13a with isothermal amplification to establish a CRISPR-based diagnostic (CRISPR-Dx), providing rapid DNA or RNA detection with attomolar sensitivity and single-base mismatch specificity. We use this Cas13a-based molecular detection platform, termed SHERLOCK (Specific High Sensitivity Enzymatic Reporter UnLOCKing), to detect specific strains of Zika and Dengue virus, distinguish pathogenic bacteria, genotype human DNA, and identify cell-free tumor DNA mutations. Furthermore, SHERLOCK reaction reagents can be lyophilized for cold-chain independence and long-term storage, and readily reconstituted on paper for field applications.
